Uncovering the molecular contributors to increased AD risk among individuals with a parental history of AD (NIA K01)
Amount
Not specified
Deadline✓ Verified
Jun 30, 2031
Funder
National Institute on Aging
Eligible
open to all
About This Grant
PROJECT SUMMARY / ABSTRACT An individual’s risk of developing Alzheimer’s disease (AD) is estimated to be up to 4 times greater if they had a parent who was diagnosed with AD. The applicant’s prior work showed that cognitively unimpaired older adults with a maternal history of AD dementia had elevated brain amyloid-PET (Aβ) in comparison to individuals with only paternal history of AD or no parental history of AD. This relationship remained significant even after adjusting for APOEε4 carriership, which is strongly linked to Aβ burden. By contrast, individuals with a paternal history of dementia have elevated tau-PET though no such relationship is observed with Aβ. It is critical to better understand how parental history of AD dementia impacts AD endophenotypes (e.g., Aβ, tau, and cognition) as well as why maternal and paternal history have different effects on AD risk. The overall goal of this proposed research is to uncover and characterize the molecular factors behind this increased
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