Identifying Key Molecular Differences Between Lewy Body and Alzheimer's Disease via Multi-Omics Analysis (NIA K99)
Amount
Not specified
Deadline✓ Verified
Apr 30, 2028
Funder
National Institute on Aging
Eligible
open to all
About This Grant
PROJECT SUMMARY: Dementia affects nearly 7 million Americans and includes multiple underlying pathologies that are frequently misdiagnosed due to overlapping clinical symptoms.1,2 While Alzheimer’s disease (AD) is the most common form of neurodegenerative dementia, dementia with Lewy bodies (DLB) and Parkinson’s disease dementia (PDD) are also prevalent in individuals over the age of 65.3,4 Lewy body disease (LBD) encompasses both DLB and PDD and is characterized by abnormal α-synuclein aggregates, often co-occurring with AD pathology - amyloid-β (Aβ) plaques and neurofibrillary tangles (NFTs).5 AD and LBD can affect overlapping cortical regions and present with similar symptoms, complicating diagnosis and treatment.5 A key knowledge gap lies in understanding the molecular alterations that differentiate LBD and AD. Additionally, genetic sex strongly influences disease risk, progression, and therapeutic response in neurodegenerative disorders.6,7 Addressing this requires incorporating s
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