Restoring Key Functions to the Industrialized Gut Microbiome (NCCIH R01)
Amount
Not specified
Deadline✓ Verified
Dec 31, 2030
Funder
National Center for Complementary and Integrative Health
Eligible
open to all
About This Grant
SUMMARY The gut microbiome plays a key role in modulating host metabolism and immune responses. Industrialized populations, like U.S. residents, have gut communities with reduced microbial richness and missing key functions, particularly the degradation of microbiota-accessible carbohydrates (MACs, a component of dietary fiber) and the subsequent production of fermentation products, the short-chain fatty acids (SCFAs) acetate, propionate, and butyrate. These changes are linked to increased prevalence of a broad range of inflammatory diseases such as diabetes, metabolic syndrome, and autoimmune disorders. Our human dietary intervention study (NCT03275662) shows that reintroducing high dietary MAC levels in humans fails to restore SCFA production in most healthy adults, likely due to the scarcity of MAC-fermenting microbes in industrialized guts. A minority of participants with the highest microbiota richness did show decreased inflammatory markers and increased fecal butyrate during the
This is a federal grant announcement. Review these terms and key sections before you start drafting.
A NOFO is the official document a federal agency publishes to announce available grant funding. It is the rulebook for the grant — every requirement, restriction, and evaluation criterion lives in it. Other names for the same thing: FOA, RFA, PA, NOFA, SGA. (RFP usually means a contract, not a grant.)
Eligibility
Who can and cannot apply — confirm your organization type is explicitly listed. Many NOFOs restrict to 501(c)(3)s, specific entity types, or geographic areas.
Deadline
Note the full application deadline AND any required Letter of Intent (LOI) date, which is often 30–60 days earlier.
Funding Amount
Min/max award and total program funding — this sets your budget ceiling. Some NOFOs list an expected number of awards.
Required Attachments
Every form, biosketch, budget narrative, and letter of support — missing even one can trigger automatic rejection. Make a checklist.
Review Criteria
How the application is scored (e.g., 40% significance, 30% approach, 20% investigator, 10% environment). Weight your narrative toward the highest-scoring criteria.
Page Limits
Strict page or character limits per section — exceeding them can disqualify your application. Note the font size, margin, and formatting rules too.
Pro tip: Read the NOFO three times before writing. Most rejected applications fail because the applicant didn't follow the instructions — not because the project was bad.
Full Guided Workflow Available
This grant has a funder website. Start the application to access the step-by-step workflow with Eligibility verification, Quick Start narrative skeleton, PDF upload, AI Writing Coach, and submission tracking.
Start Your Application
Begin your guided application workflow — you can optionally run the AI eligibility check first to see how well you fit.
Generate a section-by-section application guide
Get a lightweight blueprint: section names, suggested lengths, key points to include, strategy tips, and a compliance checklist.
AI will analyze the grant's eligibility criteria, description, and target audience to extract individual requirements.
Open to researchers, universities, and institutions