Discovery and Development of Millipede Alkaloids as a New Generation of Painkillers (NCCIH R21)
Amount
Not specified
Deadline✓ Verified
Jun 30, 2028
Funder
National Center for Complementary and Integrative Health
Eligible
open to all
About This Grant
Project summary/abstract New medicines that effectively and safely treat chronic pain are desperately needed, as it is estimated that nearly 20% of the global population actively struggles with this debilitating disease. Opioids, the current standard of care for the treatment of moderate to severe pain, have significant side effects that include respiratory depression and addictive properties, and there are barriers to their equitable use around the globe. In the search for alternatives to opioid analgesics, sigma-1 (σ1R) and sigma-2 (σ2R) receptors are intriguing targets for drug development. σ1R and σ2R ligands can produce analgesia directly, can modulate mu opioid receptor-mediated analgesia, and may be particularly useful for neuropathic pain. Arthropod defensive secretions have been a source of potential new analgesics, with metabolites targeting a variety of neuroreceptors. Chemical investigations into millipedes, a diverse class (Diplopoda) of arthropods, reveal that millipedes
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