Characterizing the Endometriosis Microbiome and Metabolomic Pain Phenotype (NCCIH K08)
Amount
Not specified
Deadline✓ Verified
Jun 30, 2031
Funder
National Center for Complementary and Integrative Health
Eligible
open to all
About This Grant
PROJECT SUMMARY Endometriosis affects 200 million individuals globally and is responsible for 87% of chronic pelvic pain. Substantial risks of non-treatment include chronic pain, kidney failure, and bowel obstruction. Disappointingly, more than one-third of individuals fail medical treatments, and fertility-sparing surgical management results in persistent pain in over 37% of cases with long-term recurrence rates close to 50%. The U.S. spends over $69 billion annually as a result of limited effective treatment options for individuals with endometriosis. Growing evidence suggests that alterations in microbial composition and nicotinamide adenine dinucleotide (NAD+)- dependent mechanisms exist in endometriosis and contribute to pain. Determining the contribution of microbiome and NAD+ metabolomic networks, and possible synergies between them is critical to understanding the biology of endometriosis pain. Our proposal aims to stratify individuals with endometriosis into groups that may be
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