PROBE: Probiotic Regulation Of Gut-Microbiome-Brain Interactions in Obesity and Eating Behaviors (NCCIH R01)
Amount
Not specified
Deadline✓ Verified
Jul 31, 2031
Funder
National Center for Complementary and Integrative Health
Eligible
open to all
About This Grant
PROJECT SUMMARY/ABSTRACT One specific area that has garnered attention is the microbiome-gut-brain (MGB) axis - a bidirectional signaling system between the gut and the brain. While targeting the microbiome in obesity has demonstrated some efficacy in improving insulin sensitivity and adiposity, the involvement of “gut-brain interactions” in these processes is unclear. This is because few studies have examined the role of the microbiome in modulating the reward network, the brainstem and its associated nuclei after a targeted gut-directed treatment (e.g., probiotics), especially in humans. Obesity continues to represent a major health epidemic, with a very high financial burden and with implications for the development of preventable chronic disease. This translates to an urgent need for therapeutic strategies that complement existing approaches, preferably interventions that can be personalized, are cost effective, and easy to implement. Moreover, because obesity is so heterogeneous w
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