Neurobiology of Pain Catastrophizing in Burn Survivors: Identification and Targeting of a Critical Treatment Mechanism (NCCIH R01)
Amount
Not specified
Deadline✓ Verified
Jun 30, 2031
Funder
National Center for Complementary and Integrative Health
Eligible
open to all
About This Grant
Abstract Each year, approximately ½ million people in the U.S. sustain and receive medical treatment for burn injuries. Pain is particularly prevalent (>50% of burn survivors) and disabling following burns, and both burn- related tissue injury as well as the procedures required for wound care can initiate severe and long-lasting chronic pain. As pain is known to be strongly modulated by negative affect, and catastrophizing in particular, the pain-reducing effects of many non-pharmacologic treatments appear to be due partially to their effects on cognitive-emotional processes such as catastrophizing. For example, studies of cognitive-behavioral therapy (CBT) frequently identify catastrophizing as a critical mechanistic variable, reductions in which are linked to improvements in pain, and CBT has been shown to improve pain in several studies with burn-injury survivors. Importantly, the neurobiology supporting catastrophizing in burn survivors is unknown and objective catastrophizing-lin
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