Developing and Validating a Multi-Omic, Psychosocial, and Environmental Model of Individual Differences in Pain and Placebo Responses (NCCIH R01)
Amount
Not specified
Deadline✓ Verified
Aug 31, 2030
Funder
National Center for Complementary and Integrative Health
Eligible
open to all
About This Grant
This project investigates chronic pain conditions, particularly temporomandibular disorder (TMD), focusing on the variability in pain sensitivity, treatment responses, and comorbidities such as depression and anxiety. A key mechanism influencing pain experience is endogenous pain modulation (EPM), which involves neural pathways that inhibit nociceptive signaling. Placebo hypoalgesia, a form of EPM, is known to depend on psychological, genetic, and environmental factors. Although much is known about the factors contributing to placebo responses, the reasons for individual differences in placebo efficacy remain poorly understood. It is also unclear how EPM influences pain severity and chronic pain severity. Current knowledge includes the finding that pain catastrophizing dimensions (rumination, magnification, helplessness) mediate the relationship between psychological factors and chronic pain severity. Additionally, jaw function, psychological distress, chronic overlapping pain conditio
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