Molecular mechanisms of phytocannabinoid-protein interactions in the brain (NCCIH K99)
Amount
Not specified
Deadline✓ Verified
Aug 31, 2028
Funder
National Center for Complementary and Integrative Health
Eligible
open to all
About This Grant
Project Summary/Abstract Phytocannabinoids are a family of structurally diverse, neuroactive molecules increasingly recognized for their therapeutic potential due to regulatory changes and positive clinical data in pain management. However, the corresponding molecular descriptions of these biological activities remain incomplete. This is especially true for minor cannabinoids, like cannabichromenes (CBC-type), which are understudied compared to the “big two,” Δ9-THC and CBD. Furthermore, the proposed “entourage effect,” a hypothesis that combinations of phytocannabinoids may produce enhanced or unique biological outcomes, lacks a clear molecular explanation. Together, rising use and limited molecular insights highlight a critical knowledge gap: we do not know the full landscape of phytocannabinoid-protein interactions, nor how these interactions shape pharmacology. Filling this gap is critical for clarifying Cannabis biology and identifying new therapeutic opportunities in pain manage
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