Evaluating the feasibility and acceptability of expectation-optimized open-label placebo as an adjuvant treatment for chronic pain (NCCIH R34)
Amount
Not specified
Deadline✓ Verified
Aug 31, 2029
Funder
National Center for Complementary and Integrative Health
Eligible
open to all
About This Grant
Chronic pain is prevalent and is a major clinical, social, and economic problem. The incidence rate of chronic pain increased to 46% based on a national survey in the US that was conducted in 2020. The direct cost to the healthcare system is estimated to be high as $261 to 300 billion. Despite the high prevalence and high cost, an optimal treatment is not yet found to cure or manage chronic pain. Traditional pharmacological treatments for chronic pain such as the use of non-steroidal anti-inflammatory drugs (NSAIDs) has been shown to have moderate effect sizes and medications such as opioids have suffered from easily developed high drug tolerance, side effects, and potential problems of addiction. Therefore, the NIH has proposed non-pharmacological treatment as the first option for chronic pain treatment. This project aims to adapt a promising adjuvant treatment open-label placebo (OLP) with optimizing expectation management in a cohort of chronic orofacial pain. OLP are placebos that
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