Brain mechanisms supporting mindfulness-assisted psilocybin therapy for chronic pain (NCCIH R01)
Amount
Not specified
Deadline✓ Verified
Jun 30, 2031
Funder
National Center for Complementary and Integrative Health
Eligible
open to all
About This Grant
Chronic low back pain (cLBP) is the most common clinical pain condition with an average prevalence of 30% and is the leading cause for disability. The pervasiveness of cLBP has exponentially increased Medicare expenditures for steroid and opioid treatments. These staggering statistics highlight the importance of identifying the active mechanisms supporting fast-acting, non-pharmacological approaches that can reliably and directly assuage pain in individuals with cLBP. Chronic pain severity and corresponding comorbidities are driven by amplified sensory, self-referential, and negative affective appraisals that intensify the transition of acute to chronic pain. These maladaptive pain-related processes are mediated by interactions between the default mode network (DMN) and nociceptive relay centers such as the thalamus. Chronic LBP is further sustained by blunted reward (mesolimbic) function and pain-related anhedonia, motivational disruptions increasingly implicated in the maintenance of
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