Alleviating antibiotic-induced microbiome dysfunction by quenching the microbial redox environment (NCCIH R01)
Amount
Not specified
Deadline✓ Verified
Jun 30, 2031
Funder
National Center for Complementary and Integrative Health
Eligible
open to all
About This Grant
PROJECT SUMMARY In the U.S., nearly 300 million antibiotic prescriptions are issued annually. While these drugs are life-saving, they can cause severe microbiome-related morbidities, including C. difficile colitis, which alone is responsible for approximately 12,000 deaths per year. Antibiotic-induced damage (AID) not only increases the risk of acute infections but also contributes to long-term conditions such as obesity, diabetes, and autoimmune diseases. The growing antibiotic resistance crisis, which demands more aggressive treatments, further amplifies these risks by exacerbating damage to the gut microbiome. Recent work from our lab has demonstrated that supplementing the murine diet with fiber reduces antibiotic-induced disruptions to the GI microbiota. Building on these findings, the next critical step is to understand the mechanism of this fiber-mediated protection and to develop translatable therapies. Based on strong preliminary data collected during our R21, we hypothesize
This is a federal grant announcement. Review these terms and key sections before you start drafting.
A NOFO is the official document a federal agency publishes to announce available grant funding. It is the rulebook for the grant — every requirement, restriction, and evaluation criterion lives in it. Other names for the same thing: FOA, RFA, PA, NOFA, SGA. (RFP usually means a contract, not a grant.)
Eligibility
Who can and cannot apply — confirm your organization type is explicitly listed. Many NOFOs restrict to 501(c)(3)s, specific entity types, or geographic areas.
Deadline
Note the full application deadline AND any required Letter of Intent (LOI) date, which is often 30–60 days earlier.
Funding Amount
Min/max award and total program funding — this sets your budget ceiling. Some NOFOs list an expected number of awards.
Required Attachments
Every form, biosketch, budget narrative, and letter of support — missing even one can trigger automatic rejection. Make a checklist.
Review Criteria
How the application is scored (e.g., 40% significance, 30% approach, 20% investigator, 10% environment). Weight your narrative toward the highest-scoring criteria.
Page Limits
Strict page or character limits per section — exceeding them can disqualify your application. Note the font size, margin, and formatting rules too.
Pro tip: Read the NOFO three times before writing. Most rejected applications fail because the applicant didn't follow the instructions — not because the project was bad.
Full Guided Workflow Available
This grant has a funder website. Start the application to access the step-by-step workflow with Eligibility verification, Quick Start narrative skeleton, PDF upload, AI Writing Coach, and submission tracking.
Start Your Application
Begin your guided application workflow — you can optionally run the AI eligibility check first to see how well you fit.
Generate a section-by-section application guide
Get a lightweight blueprint: section names, suggested lengths, key points to include, strategy tips, and a compliance checklist.
AI will analyze the grant's eligibility criteria, description, and target audience to extract individual requirements.
Open to researchers, universities, and institutions