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Investigating back pain injury mechanisms associated with chronic pain behaviors (NCCIH R15)

National Center for Complementary and Integrative Health
Deadline: Aug 31, 2029

Amount

Not specified

Deadline✓ Verified

Aug 31, 2029

Funder

National Center for Complementary and Integrative Health

Eligible

open to all

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About This Grant

Summary In this project, we propose to characterize the pathophysiology of pain from non-penetrating injuries to the thoracolumbar spinal cord. The leading causes of traumatic spinal cord injury (SCI) are motor vehicle accidents (29.9%), falls (29.8%), and sports-related injuries. SCI is characterized by a complex cascade of secondary pathophysiology processes, including ischemia, oxidative stress, inflammatory responses, and apoptotic pathways, that collectively contribute to neuronal and glial damage as well as long-term deficits. A thorough understanding of these biological mechanisms is crucial to develop effective treatments and preventive strategies aimed at reducing chronic pain and improving functional recovery. Trauma-induced SCI often results in a range of chronic complications that profoundly affect the quality of life, functional independence, and overall health. One of the most prevalent and debilitating outcomes is chronic pain following the injury. Current management str

🇺🇸Source: NIH Reporter — National Institutes of Health · View original ↗
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Deadline

Aug 31, 2029

1034 days left

Questions

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Eligibility Requirements

Open to researchers, universities, and institutions

nih
federal
nccih
R15

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