Models and mechanisms of early-onset glaucoma types (NEI R01)
Amount
Not specified
Deadline✓ Verified
Jul 31, 2031
Funder
National Eye Institute
Eligible
open to all
About This Grant
SUMMARY Schlemm’s canal (SC) is an important barrier for aqueous humor outflow that regulates intraocular pressure. Intraocular pressure elevation is a major risk factor for glaucoma. SC development is affected in several types of early-onset glaucoma. Therefore, understanding the normal development of SC is clinically relevant. Endothelial cells comprising the SC are specialized and share both vascular and lymphatic traits. The molecular program underlying the development of this specialized vessel is not fully understood. With our new advances in SC developmental transcriptomics, we are able to obtain a clear view of the dynamic gene regulation during SC development. Our central hypothesis is that Apelin signaling pathway is an important mediator of SC development. The main goal of this proposal is to understand the role of Apelin signaling in SC development. We will achieve this by i) using mouse models to characterize the expression and trace the lineage of Aplnr (apelin receptor)
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