The role of retinal microsomal triglyceride transfer protein in vision (NEI R01)
Amount
Not specified
Deadline✓ Verified
Aug 31, 2030
Funder
National Eye Institute
Eligible
open to all
About This Grant
PROJECT SUMMARY Central to retinal lipid homeostasis is the regulation of input and export pathways which defines the intracellular pool of RPE lipids and which, when dysregulated, is associated with pathologic lipid accumulation, a hallmark of many degenerative retinal diseases. The RPE manages transport of lipids into and out of the neural retina (NR) and, uptake of fat-soluble vitamins from the choroid as well as the metabolism of ingested outer segment (OS) lipids, lipid recycling to NR and de novo lipid synthesis. Much of the lipid pool in RPE is stored in lipid droplets (LD); while likely initially protective excess accumulation of LD can induce cellular dysfunction and toxicity. Lipid packaging and transport occurs via apoprotein B (APOB) containing lipoproteins (Blps); these specialized lipid transport particles made up of structural apo-proteins hold together a lipid core rich in triglycerides and esterified cholesterol. Through the assembly and section of Blps, lipids can be
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