Revealing distinct proliferation and metabolic properties of polyploid cells using the Drosophila eye (NEI F31)
Amount
Not specified
Deadline✓ Verified
Aug 31, 2029
Funder
National Eye Institute
Eligible
open to all
About This Grant
Abstract Though polyploidy exists throughout every branch in the tree of life, traits of this cellular state are largely unexplored. This grant looks to determine novel transcriptional and metabolic alterations of polyploid cells during tissue growth. Using an inducible endocycling transgenic system, we can produce a large percentage of tetraploid cells in the developing Drosophila eye. First, within the context of the developing Drosophila eye, I have identified polyploid cells to have increased fitness when compared to diploid cells due to a bias in their abundance when compared to diploid cells. I will characterize proliferation dynamics between ploidies to determine how polyploid cells become the primary ploidy in the developing Drosphila eye. Additionally, I will characterize the genetic basis for this bias towards polyploid cells. Second, through a large reverse-genetic screen in the Drosophila eye, the branch chain amino acid (BCAA) catabolism pathway was found to be a strong de
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