Therapeutic Drug Monitoring in Uveitis for Long-term Individualized Patient Care (NEI R01)
Amount
Not specified
Deadline✓ Verified
Aug 31, 2031
Funder
National Eye Institute
Eligible
open to all
About This Grant
PROJECT SUMMARY Non-infectious uveitis (NIU) is a significant cause of blindness globally and often requires systemic immunosuppression for long-term control of inflammation. Adalimumab (ADA), a monoclonal antibody to TNF- α, plays a pivotal role in the management of NIU and has changed the treatment landscape and clinical outcomes for many autoimmune conditions. Adalimumab is the most common biologic therapeutic prescribed for NIU, but its use has limitations, including primary nonresponse and loss of response due to mechanistic failure or pharmacokinetic failure both immune-mediated and non-immune-mediated. Therapeutic drug monitoring is the measurement of serum ADA trough concentration and anti-ADA antibody levels and offers an opportunity to optimize treatment with ADA. Specifically, this information can help determine therapeutic ranges for treatment response, optimize clinical response, and provide helpful additional information to manage loss of response. This prospective multi-
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